Dozens of others were also injured in the uprising that began during an alleged escape attempt, the National Assembly's representative for Portuguesa Maria Beatriz Martina told CNN. Martinez said a grenade exploded during the escape attempt, causing injuries to at least one officer.
The prison's director, Carlos Toro, is among the injured, according to the Venezuelan Prisons Observatory, which works to improve the human rights of prisoners, according to the website.
Martina tweeted that the uprising "is a clear reflection" of Venezuela's failed state. She also criticized Venezuela's Foreign Minister Iris Varela's human rights reform plan for prison.
The Department of Prisons and the Ministry of Information have not yet responded to CNN's request for comment.