Uber has teamed up with AA and Unilever to implement the new measures, which will be launched on 400 cars in Newcastle, Sunderland and Durham.
Jamie Heywood, Uber's regional general manager for northern and eastern Europe, said: “The safety of passengers and drivers using the Uber app is our number one priority.
"For weeks, we have asked people to stay at home and make only essential trips.
"When people start thinking about moving again, we hope that our pilot in North East England will help to better understand how to get people from A to B as safely as possible."
The cleaning kits will include a range of products to ensure that Uber cars are as germ-free as possible, including hand gel and antibacterial spray.
In the meantime, Uber will also distribute more than 2.2 million masks to its drivers and post office.
Alan Jope, CEO of Unilever, said: “As some countries around the world seek to slowly ease the block, safe transport will play a crucial role as we move to a new normal.
“And when people start venturing out, we need to collectively ensure that health and safety remains the top priority.
"We are pleased to partner with Uber and provide our trusted hygiene products, Unilever can help keep drivers, couriers and passengers as safe as possible."
Amid the pandemic, Uber also introduced 25% discounts for all NHS and home care employees.
The NHS team can also receive a discount of up to 50% when ordering food in some restaurants through the Uber Eats app, including LEON, Krispy Kreme, Pret A Manger and Costa Coffee.