It can mean going to a movie in Georgia, training with a personal trainer in Colorado or dropping off a dispensary in Nevada.
And several measures will be wiped out from Monday. The fitness center and gyms will open again in Arkansas May 4, while hairdressing salons will follow on May 6. In Northern California's Yuba and Sutter counties, restaurants, tattoo parlors and malls will all be open Monday, which will also be the first working day for many Colorado offices, with operations limited to 50% capacity.
In Montana, bars and breweries will also be allowed to offer some established services starting Monday.
The changes come even as experts warned Friday that premature lifting measures could be fatal.
"You make a big mistake. It will cost lives," Dr. Irwin Redlener, pediatrician and emergency preparedness specialist at Columbia University Medical Center, told CNN Friday.
In a report, Redlener and Joseph Fair, a senior fellow in pandemic politics at Texas A&M University, said no city or state should begin to reduce restrictions until coronavirus infections have been steadily declining for 10 days to two weeks, and not until that's enough tests available to track how many people are really infected.
"We ask you to do everything in your power to make sure we have the testing and contact tracking we need to get ahead safely. Until we get there, it is inappropriate and dangerous to reopen local businesses," Redlener wrote in a letter that came with reporting.
CDC: Summer will be critical in the fight against viruses
How the country's price in the next few months will be "critical" in the fight against coronavirus and how it will develop this fall, said Dr. Anne Schuchat, chief executive of the US Centers for Disease Control and Prevention.
"The more we intensify testing and expand public health capacity and ensure that our hospital capacity and materials to support hospitals are adequate or have surplus, the better we will be in the fall," Schuchat said in an interview with JAMA Network.
"If by that time we have put in place all the measures you need to address this, we should do reasonably well," he said. "If we don't do it successfully, we can be in a bad fall and a bad winter."
Fauci has also warned that early action could lead to a rebound of the virus that could put the United States in the "same boat as we were a few weeks ago."
Protest against orders leads to more than two dozen arrests
Many governors have faced resistance in recent weeks from residents who want repeal measures lifted and businesses reopened.
In California, more than 30 people were arrested Friday during a capital building demonstration to protest Govin Newsom's home order, CNN affiliate KCRA reported.
More than 1,000 people had gathered, some waved American flag and sign against order.
"This disease does not know whether you are a demonstrator, a Democrat, a Republican," the governor said Friday. "Protect Yourself, Protect Your Family, Your Kids, Your Parents, Your Grandparents, Your Neighbors."
"I appreciate the expressions, the views," Newsom said, "but we're interested in evidence, and the evidence shows some good things, but some yellow flags with caution."
Newsom said the state is "days, not weeks" away from starting to lift the restrictions.
"I just want people to know that we're getting really close to making really meaningful enlargements to the home-on scheme," the governor said in his daily coronavirus orientation.
The governor issued the order after shutting out beach travelers who packed some shores in the state under scorching temperatures last weekend.
FDA approves strap divider
This is the first authorized anti-virus therapy in the country, said FDA Commissioner Stephen Hahn.
"This is an important clinical advance that showed a statistically significant reduction in recovery time for patients with Covid-19 and is the first authorized treatment for Covid-19." Sa Hahn.
The drug was approved just days after scientists said it can help patients recover faster after infection.
In an emergency authorization on Friday, the agency said the benefits of using the drug outweighed the risk.
Here's what else happened this week:
- A model often cited by the White House increased its predictions for the US death toll by Augustpartly due to measures lifted too soon.
- States across the United States has asked for more antibody testing to be done, while others have started hiring contact trackers to get an idea of how widespread the virus has been.
- CDC said international travel and lack of testing driven the spread of the virus in the first days of the US outbreak.
- The experts say The virus is likely to continue to spread for up to two more years – up to 60 to 70% of the population has been infected.
CNN's Jennifer Henderson, Maggie Fox, Gisela Crespo, Sarah Moon, Arman Azad and Nicole Chavez contributed to this report.